Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population.

ABSTRACT:

Background

Asthma and allergy represent complex phenotypes, which disproportionately burden ethnic minorities in the United States. Strong evidence for genomic factors predisposing subjects to asthma/allergy is available. However, methods to utilize this information to identify high risk groups are variable and replication of genetic associations in African Americans is warranted.

Methods

We evaluated 41 single nucleotide polymorphisms (SNP) and a deletion corresponding to 11 genes demonstrating association with asthma in the literature, for association with asthma, atopy, testing positive for food allergens, eosinophilia, and total serum IgE among 141 African American children living in Detroit, Michigan. Independent SNP and haplotype associations were investigated for asso

SUBMITTER: Joubert BR 

PROVIDER: S-EPMC3048491 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature