Modeling the evolution of a classic genetic switch.

ABSTRACT:

Background

The regulatory network underlying the yeast galactose-use pathway has emerged as a model system for the study of regulatory network evolution. Evidence has recently been provided for adaptive evolution in this network following a whole genome duplication event. An ancestral gene encoding a bi-functional galactokinase and co-inducer protein molecule has become subfunctionalized as paralogous genes (GAL1 and GAL3) in Saccharomyces cerevisiae, with most fitness gains being attributable to changes in cis-regulatory elements. However, the quantitative functional implications of the evolutionary changes in this regulatory network remain unexplored.

Results

We develop a modeling framework to examine the evolution of the GAL regulatory network. This enables us to translat

SUBMITTER: Josephides C 

PROVIDER: S-EPMC3048525 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature