Spinal toll like receptor 3 is involved in chronic pancreatitis-induced mechanical allodynia of rat.

ABSTRACT:

Background

Mechanisms underlying pain in chronic pancreatitis (CP) are incompletely understood. Our previous data showed that astrocytes were actively involved. However, it was unclear how astrocytic activation was induced in CP conditions. In the present study, we hypothesized that toll-like receptors (TLRs) were involved in astrocytic activation and pain behavior in CP-induced pain.

Results

To test our hypothesis, we first investigated the changes of TLR2-4 in the rat CP model induced by intrapancreatic infusion of trinitrobenzene sulfonic acid (TNBS). Western blot showed that after TNBS infusion, TLR3, but not TLR2 or TLR4, was increased gradually and maintained at a very high level for up to 5 w, which correlated with the changing course of mechanical allodynia. Double i

SUBMITTER: Qian NS 

PROVIDER: S-EPMC3048572 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature