Vertebrate paralogous MEF2 genes: origin, conservation, and evolution.

ABSTRACT:

Background

The myocyte enhancer factor 2 (MEF2) gene family is broadly expressed during the development and maintenance of muscle cells. Although a great deal has been elucidated concerning MEF2 transcription factors' regulation of specific gene expression in diverse programs and adaptive responses, little is known about the origin and evolution of the four members of the MEF2 gene family in vertebrates.

Methodology/principal findings

By phylogenetic analyses, we investigated the origin, conservation, and evolution of the four MEF2 genes. First, among the four MEF2 paralogous branches, MEF2B is clearly distant from the other three branches in vertebrates, mainly because it lacks the HJURP_C (Holliday junction recognition protein C-terminal) region. Second, three duplication

SUBMITTER: Wu W 

PROVIDER: S-EPMC3048864 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature