Inhibition by cigarette smoke of nuclear factor-κB-dependent response to bacteria in the airway.

ABSTRACT: Although individuals exposed to cigarette smoke are more susceptible to respiratory infection, the effects of cigarette smoke on pulmonary defense are incompletely understood. Based on the observation that interactions between bacteria and host cells result in the expression of critical defense genes regulated by NF-κB, we hypothesized that cigarette smoke alters NF-κB function. In this study, primary human tracheobronchial epithelial cells were treated with cigarette smoke extract (CSE) and exposed to Haemophilus influenzae, and the effects of CSE on bacteria-induced signaling and gene expression were assessed. CSE inhibited high concentrations of induced NF-κB activation and the consequent expression of defense genes that occurred in airway epithelial cells in response to H. influenzae.

SUBMITTER: Manzel LJ 

PROVIDER: S-EPMC3049229 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature