Geosmithia argillacea: an emerging cause of invasive mycosis in human chronic granulomatous disease.

ABSTRACT:

Background

Chronic granulomatous disease (CGD) is an inherited disorder of the nicotinamide adenine dinucleotide phosphate oxidase that leads to defective production of microbicidal superoxide and other oxidative radicals, resulting in increased susceptibility to invasive infections, especially those due to fungi.

Methods

Geosmithia argillacea was identified from cultured isolates by genomic sequencing of the internal transcribed spacer region. Isolates previously identified as Paecilomyces variotii, a filamentous fungus closely resembling G. argillacea, were also examined.

Results

We identified G. argillacea as the cause of invasive mycosis in 7 CGD patients. In 5 cases, the fungus had been previously identified morphologically as P. variotii. All patients had pulmon

SUBMITTER: De Ravin SS 

PROVIDER: S-EPMC3049339 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature