Environment-responsive transcription factors bind subtelomeric elements and regulate gene silencing.

ABSTRACT: Subtelomeric chromatin is subject to evolutionarily conserved complex epigenetic regulation and is implicated in numerous aspects of cellular function including formation of heterochromatin, regulation of stress response pathways and control of lifespan. Subtelomeric DNA is characterized by the presence of specific repeated segments that serve to propagate silencing or to protect chromosomal regions from spreading epigenetic control. In this study, analysis of genome-wide chromatin immunoprecipitation and expression data, suggests that several yeast transcription factors regulate subtelomeric silencing in response to various environmental stimuli through conditional association with proto-silencing regions called X elements. In this context, Oaf1p, Rox1p, Gzf1p and Phd1p control the propag

SUBMITTER: Smith JJ 

PROVIDER: S-EPMC3049408 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature