Targeting BRAF for patients with melanoma.
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ABSTRACT:
SUBMITTER: Arkenau HT
PROVIDER: S-EPMC3049553 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Publications
Targeting BRAF for patients with melanoma.
Arkenau H-T HT Kefford R R Long G V GV
British journal of cancer 20101207 3
The prognosis of patients with metastatic melanoma is poor and not influenced by systemic therapy with cytotoxic drugs. New targeted agents directed against the RAS-RAF-MEK-ERK pathway show promising activity in early clinical development and particular interest is focused on selective inhibitors of mutant BRAF, which is present in one half of the cases of metastatic melanoma. The majority of patients on early trials of these drugs develop secondary resistance and subsequent disease progression ...[more]
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