Inflammatory markers are associated with risk of colorectal cancer and chemopreventive response to anti-inflammatory drugs.

ABSTRACT:

Background & aims

Aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) lower the risk of colorectal cancer (CRC). We investigated whether plasma inflammatory markers were associated with risk of CRC and if use of anti-inflammatory drugs was differentially associated with risk of CRC according to levels of inflammatory markers.

Methods

We measured levels of high-sensitivity C-reactive protein (CRP), interleukin (IL)-6, and the soluble tumor necrosis factor receptor 2 (sTNFR-2) in blood samples from 32,826 women, collected from 1989 to 1990. Through 2004, we documented 280 cases of incident CRC; each case was matched for age to 2 randomly selected participants without cancer (controls). Information on anti-inflammatory drug (aspirin and NSAIDs) use was collected bienniall

SUBMITTER: Chan AT 

PROVIDER: S-EPMC3049858 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature