Ontology highlight
ABSTRACT:
SUBMITTER: Novershtern N
PROVIDER: S-EPMC3049864 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Cell 20110101 2
Though many individual transcription factors are known to regulate hematopoietic differentiation, major aspects of the global architecture of hematopoiesis remain unknown. Here, we profiled gene expression in 38 distinct purified populations of human hematopoietic cells and used probabilistic models of gene expression and analysis of cis-elements in gene promoters to decipher the general organization of their regulatory circuitry. We identified modules of highly coexpressed genes, some of which ...[more]