Expectation and temperament moderate amygdala and dorsal anterior cingulate cortex responses to fear faces.

ABSTRACT: A chronic tendency to avoid novelty is often the result of a temperamental bias called inhibited temperament, and is associated with increased risk for anxiety disorders. Neuroimaging studies have demonstrated that an inhibited temperament is associated with increased amygdalar blood-oxygenation-level-dependent (BOLD) response to unfamiliar faces that were not expected; however, the effects of variations in expectancy remain unknown. Using functional magnetic resonance imaging (fMRI), we studied BOLD response to infrequently encountered fear faces that were either expected or not expected in 42 adults with an inhibited or an uninhibited temperament. Individuals with an inhibited temperament had greater amygdala, but less dorsal anterior cingulate cortex (dACC), BOLD response when the stimu

SUBMITTER: Clauss JA 

PROVIDER: S-EPMC3049952 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature