Abnormalities of angiotensin regulation in postural tachycardia syndrome.

ABSTRACT:

Background

Postural tachycardia syndrome (POTS) is a disorder characterized by excessive orthostatic tachycardia and significant functional disability. We previously reported that POTS patients have low blood volume and inappropriately low plasma renin activity (PRA) and aldosterone. In this study, we sought to more fully characterize the renin-angiotensin-aldosterone system (RAAS) to gain a better understanding of the pathophysiology of POTS.

Objective

The purpose of this study was to prospectively assess the plasma levels of angiotensin (Ang) peptides and their relationship to other RAAS components in patients with POTS compared with healthy controls.

Methods

Heart rate, PRA, Ang I, Ang II, Ang (1-7), and aldosterone were measured in POTS patients (n = 38) and healt

SUBMITTER: Mustafa HI 

PROVIDER: S-EPMC3050076 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature