Thiazolidinediones and fractures: evidence from translating research into action for diabetes.

ABSTRACT:

Background

Thiazolidinedione (TZD) treatment has been associated with fractures. The purpose of this study was to examine the association between TZD treatment and fractures in type 2 diabetic patients.

Methods

Using data from Translating Research into Action for Diabetes, a multicenter prospective observational study of diabetes care in managed care, we conducted a matched case-control study to assess the odds of TZD exposure in patients with type 2 diabetes with and without fractures. We identified 786 cases based on fractures detected in health plan administrative data. Up to four controls without any fracture diagnoses were matched to each case. Controls were matched on health plan, date of birth within 5 yr, sex, race/ethnicity, and body mass index within 5 kg/m(2). We

SUBMITTER: Bilik D 

PROVIDER: S-EPMC3050101 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature