Reversible sympathetic overactivity in hypertensive patients with primary aldosteronism.

ABSTRACT:

Context

Aldosterone has been shown to exert a central sympathoexcitatory action in multiple animal models, but evidence in humans is still lacking.

Objectives

Our objective was to determine whether hyperaldosteronism causes reversible sympathetic activation in humans.

Methods

We performed a cross-sectional comparison of muscle sympathetic nerve activity (SNA, intraneural microelectrodes) in 14 hypertensive patients with biochemically proven primary aldosteronism (PA) with 20 patients with essential hypertension (EH) and 18 age-matched normotensive (NT) controls. Seven patients with aldosterone-producing adenoma (APA) were restudied 1 month after unilateral adrenalectomy.

Results

Mean blood pressure values in patients with PA and EH and NT controls was 145 ± 4/8

SUBMITTER: Kontak AC 

PROVIDER: S-EPMC3050103 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature