Kinetics of the post-onset decline in zinc transporter 8 autoantibodies in type 1 diabetic human subjects.

ABSTRACT:

Context

Zinc transporter 8 (ZnT8) is a newly discovered islet autoantigen in human type 1A diabetes (T1D).

Objective

The objective was to document changes in ZnT8 autoantibody (ZnT8A) titer and prevalence after onset of disease in relationship to 65 kDa glutamate decarboxylase antibody (GADA) and islet cell antigen antibody (IA2A).

Design/patients

Autoantibody radioimmunoprecipitation assays were performed on sera from three groups: 21 individuals monitored every 3 months from diagnosis for 2.5 yr; 61 individuals monitored at six monthly intervals for 5-12 yr; and a cross-sectional study of 424 patients with T1D of 20-57 yr duration. Circulating C-peptide was determined as an index of residual β-cell function.

Results

ZnT8A titers declined exponentially from cl

SUBMITTER: Wenzlau JM 

PROVIDER: S-EPMC3050104 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature