HIV-1 Tat-induced platelet activation and release of CD154 contribute to HIV-1-associated autoimmune thrombocytopenia.

ABSTRACT:

Background

Enhanced platelet activation in human immunodeficiency virus (HIV)-1-infected patients has been reported and shown to strongly correlate with plasma viral load. Activated platelets are known to express and to release a variety of proteins that can modulate the immune system. Specifically, platelet-derived CD154 has been shown to be directly involved in the development of autoimmune thrombocytopenia (ITP). The mechanism by which HIV-1 infection leads to platelet activation and the effect of this activation on the development of HIV-1 ITP, however, is not fully understood.

Objective

We have investigated the effect of HIV-1 Trans activating factor (Tat) on platelet activation.

Results

We report that HIV-1 Tat directly interacts with platelets and induces plate

SUBMITTER: Wang J 

PROVIDER: S-EPMC3050111 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature