Endocrine disruptors, environmental oxygen, epigenetics and pregnancy.

ABSTRACT: The placenta and its myriad functions are central to successful reproductive outcomes. These functions can be influenced by the environment encountered throughout pregnancy, thereby altering the appropriate genetic programming needed to allow for sustained pregnancy and appropriate fetal development. This altered programming may result from epigenetic alterations related to environmental exposures. Epigenetic alterations are now being linked to several important reproductive outcomes, including early pregnancy loss, intrauterine growth restriction, congenital syndromes, preterm birth, and preeclampsia. The diversity of environmental exposures linked to adverse reproductive effects continues to grow. Much attention has focused on the role of endocrine disruptors in infertility, but recent w

SUBMITTER: Robins JC 

PROVIDER: S-EPMC3050574 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature