Ontology highlight
ABSTRACT:
SUBMITTER: Erler JT
PROVIDER: S-EPMC3050620 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Cancer cell 20090101 1
Tumor cell metastasis is facilitated by "premetastatic niches" formed in destination organs by invading bone marrow-derived cells (BMDCs). Lysyl oxidase (LOX) is critical for premetastatic niche formation. LOX secreted by hypoxic breast tumor cells accumulates at premetastatic sites, crosslinks collagen IV in the basement membrane, and is essential for CD11b+ myeloid cell recruitment. CD11b+ cells adhere to crosslinked collagen IV and produce matrix metalloproteinase-2, which cleaves collagen, e ...[more]