Analysis of antibody and cytokine markers for leprosy nerve damage and reactions in the INFIR cohort in India.

ABSTRACT:

Background

The ILEP Nerve Function Impairment in Reaction (INFIR) is a cohort study designed to identify predictors of reactions and nerve function impairment (NFI) in leprosy.

Aim of the study

Antibodies to mycobacteria, nerve components and serum cytokine were measured as potential markers for their possible association with reactions and NFI.

Patients and methods

303 newly diagnosed leprosy patients from two centres in North India were enrolled. Antibodies to PGL-1, LAM (IgG1 and IgG3), ceramide, S100 and TNFα levels were measured using ELISA techniques.

Results

S-100, PGL IgG and IgM antibody levels were lowest in patients with BT leprosy and highest in patients with lepromatous leprosy. LAM IgG1 and LAM IgG3 antibody levels were highest in patients with BL

SUBMITTER: Jadhav R 

PROVIDER: S-EPMC3050910 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature