Identifying dispersed epigenomic domains from ChIP-Seq data.

ABSTRACT:

Motivation

Post-translational modifications to histones have several well known associations with regulation of gene expression. While some modifications appear concentrated narrowly, covering promoters or enhancers, others are dispersed as epigenomic domains. These domains mark contiguous regions sharing an epigenomic property, such as actively transcribed or poised genes, or heterochromatically silenced regions. While high-throughput methods like ChIP-Seq have led to a flood of high-quality data about these epigenomic domains, there remain important analysis problems that are not adequately solved by current analysis tools.

Results

We present the RSEG method for identifying epigenomic domains from ChIP-Seq data for histone modifications. In contrast with other methods emph

SUBMITTER: Song Q 

PROVIDER: S-EPMC3051331 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature