A portrait of the transcriptome of the neglected trematode, Fasciola gigantica--biological and biotechnological implications.

ABSTRACT: Fasciola gigantica (Digenea) is an important foodborne trematode that causes liver fluke disease (fascioliasis) in mammals, including ungulates and humans, mainly in tropical climatic zones of the world. Despite its socioeconomic impact, almost nothing is known about the molecular biology of this parasite, its interplay with its hosts, and the pathogenesis of fascioliasis. Modern genomic technologies now provide unique opportunities to rapidly tackle these exciting areas. The present study reports the first transcriptome representing the adult stage of F. gigantica (of bovid origin), defined using a massively parallel sequencing-coupled bioinformatic approach. From >20 million raw sequence reads, >30,000 contiguous sequences were assembled, of which most were novel. Relative levels of tran

SUBMITTER: Young ND 

PROVIDER: S-EPMC3051338 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature