MUC4 gene polymorphisms associate with endometriosis development and endometriosis-related infertility.

ABSTRACT:

Background

Mucin 4 (MUC4) plays an important role in protecting and lubricating the epithelial surface of reproductive tracts, but its role in the pathogenesis of endometriosis is largely unknown.

Methods

To correlate MUC4 polymorphism with the risk of endometriosis and endometriosis-related infertility, we performed a case-control study of 140 patients and 150 healthy women. Six unique single-nucleotide polymorphisms (SNPs) (rs882605, rs1104760, rs2688513, rs2246901, rs2258447 and rs2291652) were selected for this study. DNA fragments containing the target SNP sites were amplified by polymerase chain reaction using the TaqMan SNP Genotyping Assay System to evaluate allele frequency and distribution of genotype in MUC4 polymorphisms.

Results

Both the T/G genotype of r

SUBMITTER: Chang CY 

PROVIDER: S-EPMC3052195 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature