Effects of oxidative stress on behavior, physiology, and the redox thiol proteome of Caenorhabditis elegans.

ABSTRACT: Accumulation of reactive oxygen species has been implicated in various diseases and aging. However, the precise physiological effects of accumulating oxidants are still largely undefined. Here, we applied a short-term peroxide stress treatment to young Caenorhabditis elegans and measured behavioral, physiological, and cellular consequences. We discovered that exposure to peroxide stress causes a number of immediate changes, including loss in mobility, decreased growth rate, and decreased cellular adenosine triphosphate levels. Many of these alterations, which are highly reminiscent of changes in aging animals, are reversible, suggesting the presence of effective antioxidant systems in young C. elegans. One of these antioxidant systems involves the highly abundant protein peroxiredoxin 2 (P

SUBMITTER: Kumsta C 

PROVIDER: S-EPMC3052275 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature