Replication of genome-wide association studies (GWAS) loci for fasting plasma glucose in African-Americans.

ABSTRACT:

Aims/hypothesis

Chronically elevated blood glucose (hyperglycaemia) is the primary indicator of type 2 diabetes, which has a prevalence that varies considerably by ethnicity in the USA, with African-Americans disproportionately affected. Genome-wide association studies (GWASs) have significantly enhanced our understanding of the genetic basis of diabetes and related traits, including fasting plasma glucose (FPG). However, the majority of GWASs have been conducted in populations of European ancestry. Thus, it is important to conduct replication analyses in populations with non-European ancestry to identify shared loci associated with FPG across populations.

Methods

We used data collected from non-diabetic unrelated African-American individuals (n = 927) who participated in th

SUBMITTER: Ramos E 

PROVIDER: S-EPMC3052446 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature