Modeling vesicle traffic reveals unexpected consequences for Cdc42p-mediated polarity establishment.

ABSTRACT:

Background

Polarization in yeast has been proposed to involve a positive feedback loop whereby the polarity regulator Cdc42p orients actin cables, which deliver vesicles carrying Cdc42p to the polarization site. Previous mathematical models treating Cdc42p traffic as a membrane-free flux suggested that directed traffic would polarize Cdc42p, but it remained unclear whether Cdc42p would become polarized without the membrane-free simplifying assumption.

Results

We present mathematical models that explicitly consider stochastic vesicle traffic via exocytosis and endocytosis, providing several new insights. Our findings suggest that endocytic cargo influences the timing of vesicle internalization in yeast. Moreover, our models provide quantitative support for the view that integ

SUBMITTER: Layton AT 

PROVIDER: S-EPMC3052744 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature