Epigenetic differences in cytogenetically normal versus abnormal acute myeloid leukemia.

ABSTRACT:

Background

Methylation of tumor suppression genes (TSGs) is common in myeloid malignancies. However, application of this as a molecular marker for risk stratification in patients with AML is limited.

Design and methods

To elucidate the impact of patterns of TSG methylation on outcome in cytogenetically normal patients, 106 samples from patients with having normal cytogenetic AML were evaluated for methylation of 12 genes by MSP. For sake of comparison, samples from patients with AML and abnormal cytogenetics (n = 63) were also evaluated.

Results

Methylation frequencies in the whole group (n = 169) were similar to previous reports for CDH1 (31%), ER (31%), FHIT (9%), p15 (INK4b) (44%), p73 (25%), and SOCS1 (75%). Methylation of CTNNA1 was observed in 10%, CEBP-α in16%,

SUBMITTER: Griffiths EA 

PROVIDER: S-EPMC3052845 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature