Variable histone modifications at the A(vy) metastable epiallele.

ABSTRACT: The ability of environmental factors to shape health and disease involves epigenetic mechanisms that mediate gene-environment interactions. Metastable epiallele genes are variably expressed in genetically identical individuals due to epigenetic modifications established during early development. DNA methylation within metastable epialleles is stochastic due to probabilistic reprogramming of epigenetic marks during embryogenesis. Maternal nutrition and environment have been shown to affect metastable epiallele methylation patterns and subsequent adult phenotype. Little is known, however, about the role of histone modifications in influencing metastable epiallele expression and phenotypic variation. Utilizing chromatin immunoprecipitation followed by qPCR, we observe variable histone pattern

SUBMITTER: Dolinoy DC 

PROVIDER: S-EPMC3052847 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature