Genome-wide association studies reveal genetic variants in CTNND2 for high myopia in Singapore Chinese.

ABSTRACT:

Objective

To determine susceptibility genes for high myopia in Singaporean Chinese.

Design

A meta-analysis of 2 genome-wide association (GWA) datasets in Chinese and a follow-up replication cohort in Japanese.

Participants and controls

Two independent datasets of Singaporean Chinese individuals aged 10 to 12 years (Singapore Cohort Study of the Risk factors for Myopia [SCORM]: cases = 65, controls = 238) and more than 21 years (Singapore Prospective Study Program [SP2]: cases = 222, controls = 435) for GWA studies, and a Japanese dataset aged more than 20 years (cases = 959, controls = 2128) for replication.

Methods

Genomic DNA samples from SCORM and SP2 were genotyped using various Illumina Beadarray platforms (>HumanHap 500). Single-locus association tests we

SUBMITTER: Li YJ 

PROVIDER: S-EPMC3052933 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature