The cell adhesion-associated protein Git2 regulates morphogenetic movements during zebrafish embryonic development.

ABSTRACT: Signaling through cell adhesion complexes plays a critical role in coordinating cytoskeletal remodeling necessary for efficient cell migration. During embryonic development, normal morphogenesis depends on a series of concerted cell movements; but the roles of cell adhesion signaling during these movements are poorly understood. The transparent zebrafish embryo provides an excellent system to study cell migration during development. Here, we have identified zebrafish git2a and git2b, two new members of the GIT family of genes that encode ArfGAP proteins associated with cell adhesions. Loss-of-function studies revealed an essential role for Git2a in zebrafish cell movements during gastrulation. Time-lapse microscopy analysis demonstrated that antisense depletion of Git2a greatly reduced or

SUBMITTER: Yu JA 

PROVIDER: S-EPMC3053038 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature