Triterpene derivatives that inhibit human immunodeficiency virus type 1 replication.

ABSTRACT: Triterpene derivatives were analyzed for anti-HIV-1 activity and for cellular toxicity. Betulinic aldehyde, betulinic nitrile, and morolic acid derivatives were identified to have anti-HIV-1 activity. These derivatives inhibit a late step in virus replication, likely virus maturation.

SUBMITTER: Dorr CR 

PROVIDER: S-EPMC3053071 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature