Time course analysis of gene expression identifies multiple genes with differential expression in patients with in-stent restenosis.

ABSTRACT:

Background

The vascular disease in-stent restenosis (ISR) is characterized by formation of neointima and adverse inward remodeling of the artery after injury by coronary stent implantation. We hypothesized that the analysis of gene expression in peripheral blood mononuclear cells (PBMCs) would demonstrate differences in transcript expression between individuals who develop ISR and those who do not.

Methods and results

We determined and investigated PBMC gene expression of 358 patients undergoing an index procedure to treat in de novo coronary artery lesions with bare metallic stents, using a novel time-varying intercept model to optimally assess the time course of gene expression across a time course of blood samples. Validation analyses were conducted in an independent samp

SUBMITTER: Ganesh SK 

PROVIDER: S-EPMC3053213 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature