Human Nek6 is a monomeric mostly globular kinase with an unfolded short N-terminal domain.

ABSTRACT:

Background

The NIMA-related kinases (Neks) are widespread among eukaryotes. In mammalians they represent an evolutionarily conserved family of 11 serine/threonine kinases, with 40-45% amino acid sequence identity to the Aspergillus nidulans mitotic regulator NIMA within their catalytic domains. Neks have cell cycle-related functions and were recently described as related to pathologies, particularly cancer, consisting in potential chemotherapeutic targets. Human Nek6, -7 and -9 are involved in the control of mitotic spindle formation, acting together in a mitotic kinase cascade, but their mechanism of regulation remain elusive.

Results

In this study we performed a biophysical and structural characterization of human Nek6 with the aim of obtaining its low resolution and homol

SUBMITTER: Meirelles GV 

PROVIDER: S-EPMC3053220 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature