Spontaneous lymphatic vessel formation and regression in the murine cornea.

ABSTRACT:

Purpose

Lymphatic dysfunctions are associated with many diseases, ranging from cancer metastasis to transplant rejection, for which there is little effective treatment. To date, there is no natural model with which to study lymphatic regression. This study was conducted to investigate whether murine cornea, an extensively exploited tissue for vascular studies, derives its lymphatic-free status from a natural regression mechanism. The differential behaviors between the lymphatic and blood vessels under normal development and inflammation conditions are also compared.

Methods

Normal mouse eyeballs or whole-mount corneas encompassing the entire course of corneal development and maturation and adult inflamed corneas were used for immunofluorescent microscopic studies.

Results

SUBMITTER: Zhang H 

PROVIDER: S-EPMC3053282 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature