Chiasmata promote monopolar attachment of sister chromatids and their co-segregation toward the proper pole during meiosis I.

ABSTRACT: The chiasma is a structure that forms between a pair of homologous chromosomes by crossover recombination and physically links the homologous chromosomes during meiosis. Chiasmata are essential for the attachment of the homologous chromosomes to opposite spindle poles (bipolar attachment) and their subsequent segregation to the opposite poles during meiosis I. However, the overall function of chiasmata during meiosis is not fully understood. Here, we show that chiasmata also play a crucial role in the attachment of sister chromatids to the same spindle pole and in their co-segregation during meiosis I in fission yeast. Analysis of cells lacking chiasmata and the cohesin protector Sgo1 showed that loss of chiasmata causes frequent bipolar attachment of sister chromatids during anaphase. Fur

SUBMITTER: Hirose Y 

PROVIDER: S-EPMC3053323 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature