Progressive regional atrophy in normal adults with a maternal history of Alzheimer disease.

ABSTRACT:

Objective

Beyond age, having a family history is the most significant risk factor for Alzheimer disease (AD). This longitudinal brain imaging study examines whether there are differential patterns of regional gray matter atrophy in cognitively healthy elderly subjects with (FH+) and without (FH-) a family history of late-onset AD.

Methods

As part of the KU Brain Aging Project, cognitively intact individuals with a maternal history (FHm, n = 11), paternal history (FHp, n = 10), or no parental history of AD (FH-, n = 32) similar in age, gender, education, and Mini-Mental State Examination (MMSE) score received MRI at baseline and 2-year follow-up. A custom voxel-based morphometry processing stream was used to examine regional differences in atrophy between FH groups, controlli

SUBMITTER: Honea RA 

PROVIDER: S-EPMC3053329 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature