Global clinical dementia rating of 0.5 in MCI masks variability related to level of function.

ABSTRACT:

Objective

To evaluate whether ratings on Clinical Dementia Rating (CDR) items related to instrumental activities of daily living (IADL) are associated with cognitive or brain morphometric characteristics of participants with mild cognitive impairment (MCI) and global CDR scores of 0.5.

Methods

Baseline cognitive and morphometric data were analyzed for 283 individuals with MCI who were divided into 2 groups (impaired and intact) based on their scores on the 3 CDR categories assessing IADL. Rates of progression to Alzheimer disease (AD) over 2 years were also compared in the 2 groups.

Results

The impaired IADL MCI group showed a more widespread pattern of gray matter loss involving frontal and parietal regions, worse episodic memory and executive functions, and a higher

SUBMITTER: Chang YL 

PROVIDER: S-EPMC3053336 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature