Motor cortex inhibition: a marker of ADHD behavior and motor development in children.

ABSTRACT:

Objective

Attention-deficit/hyperactivity disorder (ADHD) is a childhood-onset behavioral diagnosis in which children often fail to meet age norms in development of motor control, particularly timed repetitive and sequential movements, motor overflow, and balance. The neural substrate of this motor delay may include mechanisms of synaptic inhibition in or adjacent to the motor cortex. The primary objective of this study was to determine whether transcranial magnetic stimulation (TMS)-evoked measures, particularly short interval cortical inhibition (SICI), in motor cortex correlate with the presence and severity of ADHD in childhood as well as with commonly observed delays in motor control.

Methods

In this case-control study, behavioral ratings, motor skills, and motor cortex

SUBMITTER: Gilbert DL 

PROVIDER: S-EPMC3053341 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature