Phylodynamics of HIV-1 from a phase III AIDS vaccine trial in Bangkok, Thailand.

ABSTRACT:

Background

In 2003, a phase III placebo-controlled trial (VAX003) was completed in Bangkok, Thailand. Of the 2,546 individuals enrolled in the trial based on high risk for infection through injection drug use (IDU), we obtained clinical samples and HIV-1 sequence data (envelope glycoprotein gene gp120) from 215 individuals who became infected during the trial. Here, we used these data in combination with other publicly available gp120 sequences to perform a molecular surveillance and phylodynamic analysis of HIV-1 in Thailand.

Methodology and findings

Phylogenetic and population genetic estimators were used to assess HIV-1 gp120 diversity as a function of vaccination treatment, viral load (VL) and CD4(+) counts, to identify transmission clusters and to investigate the timesc

SUBMITTER: Perez-Losada M 

PROVIDER: S-EPMC3053363 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature