Elucidation of functional markers from Aspergillus nidulans developmental regulator FlbB and their phylogenetic distribution.

ABSTRACT: Aspergillus nidulans is a filamentous fungus widely used as a model for biotechnological and clinical research. It is also used as a platform for the study of basic eukaryotic developmental processes. Previous studies identified and partially characterized a set of proteins controlling cellular transformations in this ascomycete. Among these proteins, the bZip type transcription factor FlbB is a key regulator of reproduction, stress responses and cell-death. Our aim here was the prediction, through various bioinformatic methods, of key functional residues and motifs within FlbB in order to inform the design of future laboratory experiments and further the understanding of the molecular mechanisms that control fungal development. A dataset of FlbB orthologs and those of its key interaction

SUBMITTER: Cortese MS 

PROVIDER: S-EPMC3053368 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature