Effect sizes in experimental pain produced by gender, genetic variants and sensitization procedures.

ABSTRACT:

Background

Various effects on pain have been reported with respect to their statistical significance, but a standardized measure of effect size has been rarely added. Such a measure would ease comparison of the magnitude of the effects across studies, for example the effect of gender on heat pain with the effect of a genetic variant on pressure pain.

Methodology/principal findings

Effect sizes on pain thresholds to stimuli consisting of heat, cold, blunt pressure, punctuate pressure and electrical current, administered to 125 subjects, were analyzed for 29 common variants in eight human genes reportedly modulating pain, gender and sensitization procedures using capsaicin or menthol. The genotype explained 0-5.9% of the total interindividual variance in pain thresholds to var

SUBMITTER: Doehring A 

PROVIDER: S-EPMC3053372 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature