Differential expression of type III effector BteA protein due to IS481 insertion in Bordetella pertussis.

ABSTRACT:

Background

Bordetella pertussis is the primary etiologic agent of the disease pertussis. Universal immunization programs have contributed to a significant reduction in morbidity and mortality of pertussis; however, incidence of the disease, especially in adolescents and adults, has increased in several countries despite high vaccination coverage. During the last three decades, strains of Bordetella pertussis in circulation have shifted from the vaccine-type to the nonvaccine-type in many countries. A comparative proteomic analysis of the strains was performed to identify protein(s) involved in the type shift.

Methodology/principal finding

Proteomic analysis identified one differentially expressed protein in the B. pertussis strains: the type III cytotoxic effector protein Bt

SUBMITTER: Han HJ 

PROVIDER: S-EPMC3053399 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature