Invasive circuitry-based neurotherapeutics: stereotactic ablation and deep brain stimulation for OCD.

ABSTRACT: Psychiatric neurosurgery, specifically stereotactic ablation, has continued since the 1940s, mainly at a few centers in Europe and the US. Since the late 1990s, the resurgence of interest in this field has been remarkable; reports of both lesion procedures and the newer technique of deep brain stimulation (DBS) have increased rapidly. In early 2009, the US FDA granted limited humanitarian approval for DBS for otherwise intractable obsessive-compulsive disorder (OCD), the first such approval for a psychiatric illness. Several factors explain the emergence of DBS and continued small-scale use of refined lesion procedures. DBS and stereotactic ablation have been successful and widely used for movement disorders. There remains an unmet clinical need: current drug and behavioral treatments offe

SUBMITTER: Greenberg BD 

PROVIDER: S-EPMC3055421 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature