The roles of dopamine and serotonin in decision making: evidence from pharmacological experiments in humans.

ABSTRACT: Neurophysiological experiments in primates, alongside neuropsychological and functional magnetic resonance investigations in humans, have significantly enhanced our understanding of the neural architecture of decision making. In this review, I consider the more limited database of experiments that have investigated how dopamine and serotonin activity influences the choices of human adults. These include those experiments that have involved the administration of drugs to healthy controls, experiments that have tested genotypic influences upon dopamine and serotonin function, and, finally, some of those experiments that have examined the effects of drugs on the decision making of clinical samples. Pharmacological experiments in humans are few in number and face considerable methodological ch

SUBMITTER: Rogers RD 

PROVIDER: S-EPMC3055502 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature