Gamma oscillatory power is impaired during cognitive control independent of medication status in first-episode schizophrenia.

ABSTRACT: Schizophrenia is characterized by impaired cognitive control associated with prefrontal cortex dysfunction, but the underlying pathophysiological mechanisms remain unknown. Higher cognitive processes are associated with cortical oscillations in the gamma range, which are also impaired in chronic schizophrenia. We tested whether cognitive control-related gamma deficits are observed in first-episode patients, and whether they are associated with antipsychotic medication exposure. Fifty-three first-episode schizophrenia patients (21 without antipsychotic medication treatment) and 29 healthy control subjects underwent electroencephalography (EEG) during performance of a preparatory cognitive control task (preparing to overcome prepotency or POP task). The first-episode schizophrenia patient gr

SUBMITTER: Minzenberg MJ 

PROVIDER: S-EPMC3055567 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature