Identification of sequence mutations affecting hemagglutinin specificity to sialic acid receptor in influenza A virus subtypes.

ABSTRACT: The attachment of the hemagglutinin protein of the H1N1 subtype of the pandemic influenza A virus to the sialic acid receptor Sia(α2-6)Gal has contributed to the ability of the virus to replicate in the human body and transmit among humans. In view of the pandemic caused by the replication and transmission of the H1N1 virus, more studies on the specificity of hemagglutinin towards sialic acid and how it affects the replication and transmission ability of this virus among humans are needed. In this study, we have applied sequence, structural and functional analyses to the hemagglutinin protein of the pandemic H1N1 virus, with the aim of identifying amino acid mutation patterns that affect its specificity to sialic acid. We have also employed a molecular docking method to evaluate the comple

SUBMITTER: Tambunan US 

PROVIDER: S-EPMC3055699 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature