Investigation of the human pathogen Acinetobacter baumannii under iron limiting conditions.

ABSTRACT:

Background

Iron acquisition systems are important virulence factors in pathogenic bacteria. To identify these systems in Acinetobacter baumannii, the transcriptomic response of the completely sequenced strain ATCC 17978 under iron limiting conditions was investigated using a genomic microarray that contained probes for all annotated open reading frames.

Results

Under low iron conditions, transcription levels were more than 2-fold up-regulated for 463 genes, including 95 genes that were up-regulated more than 4-fold. Of particular significance, three siderophore biosynthesis gene clusters, including one novel cluster, were highly up-regulated. Binding sites for the ferric uptake regulator were identified in the promoter regions of many up-regulated genes, suggesting a promine

SUBMITTER: Eijkelkamp BA 

PROVIDER: S-EPMC3055841 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature