Phenotype of atopic dermatitis subjects with a history of eczema herpeticum.

ABSTRACT:

Background

A subset of subjects with atopic dermatitis (AD) are susceptible to serious infections with herpes simplex virus, called eczema herpeticum, or vaccina virus, called eczema vaccinatum.

Objective

This National Institute of Allergy and Infectious Diseases-funded multicenter study was performed to establish a database of clinical information and biologic samples on subjects with AD with and without a history of eczema herpeticum (ADEH(+) and ADEH(-) subjects, respectively) and healthy control subjects. Careful phenotyping of AD subsets might suggest mechanisms responsible for disseminated viral infections and help identify at-risk individuals.

Methods

We analyzed the data from 901 subjects (ADEH(+) subjects, n = 134; ADEH(-) subjects, n = 419; healthy control s

SUBMITTER: Beck LA 

PROVIDER: S-EPMC3056058 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature