Total synthesis of (-)-callipeltoside A.

ABSTRACT: A total synthesis of (-)-callipeltoside A (1) has been achieved. The core macrocycle was made via a dual macrolactonization/pyran hemiketal formation reaction, developed to circumvent issues related to the reversible nature of acylketene formation from β-keto lactone substrates. Initial approaches to the core of the natural product that revolved around ring-closing metathesis (RCM) and relay ring-closing metathesis (RRCM) reactions are also described.

SUBMITTER: Hoye TR 

PROVIDER: S-EPMC3056157 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature