Conditional depletion of airway progenitor cells induces peribronchiolar fibrosis.

ABSTRACT:

Rationale

The respiratory epithelium has a remarkable capacity to respond to acute injury. In contrast, repeated epithelial injury is often associated with abnormal repair, inflammation, and fibrosis. There is increasing evidence that nonciliated epithelial cells play important roles in the repair of the bronchiolar epithelium after acute injury. Cellular processes underlying the repair and remodeling of the lung after chronic epithelial injury are poorly understood.

Objectives

To identify cell processes mediating epithelial regeneration and remodeling after acute and chronic Clara cell depletion.

Methods

A transgenic mouse model was generated to conditionally express diphtheria toxin A to ablate Clara cells in the adult lung. Epithelial regeneration and peribronchiol

SUBMITTER: Perl AK 

PROVIDER: S-EPMC3056226 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature