Genetic variation in the FAS gene and associations with acute lung injury.

ABSTRACT:

Rationale

Fas (CD95) modulates apoptosis and inflammation and is believed to play an important role in lung injury.

Objectives

To determine if common genetic variation in FAS is associated with acute lung injury (ALI) susceptibility, risk of death, and FAS gene expression.

Methods

We genotyped 14 single nucleotide polymorphisms (tagSNPS) in FAS in samples from healthy white volunteers (control subjects, n = 294) and patients with ALI (cases, n = 324) from the ARDSnet Fluid and Catheter Treatment Trial (FACTT). FAS genotypes associated with ALI in the discovery study were confirmed in a nested case-control validation study of critically ill patients at risk for ALI (n = 657). We also tested for associations between selected tagSNPS and FAS mRNA levels in whole blood fr

SUBMITTER: Glavan BJ 

PROVIDER: S-EPMC3056231 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature